HIV: CAUSES OF CONSTITUTIONAL SYMPTOMS-CYTOMEGALOVIRUS (CMV)
CMV, like the herpes viruses to which it is related, causes infection in many people, lies dormant after symptoms disappear, and can recur later. Like MAI, CMV infections are spread throughout the body, almost always when the CD4 count is less than 200, usually less than 100. In the liver, CMV causes hepatitis; in the intestines, diarrhea; in the esophagus, difficulty swallowing; in the lung, pneumonia; on the skin, herpes-like sores; in the eye, retinitis. In many people, however, CMV infection only causes constitutional symptoms, including fever, fatigue, and wasting.
One of the most serious of these infections is CMV retinitis, which, if left untreated, can cause blindness. CMV is transmitted the way HIV is, through sexual contact or contact with blood. Most people do not know when they were infected, and the initial infection usually does not cause symptoms. For these reasons, CMV is not considered a health threat to others.
CMV infection is difficult to treat: like MAI, it resists most antibiotics. The drugs
used—ganciclovir and foscarnet—must be given intravenously. CMV retinitis responds well to treatment; CMV at other places in the body responds less predictably.
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